Histone Demethylase Controls Small Molecules and Peptides

Histone demethylases are a family of enzymes that includes lysine demethylases (KDMs) and arginine demethylases. These enzymes catalyze the removal of methyl groups from lysine and arginine residues on histone tails. They reverse the methylation of lysine and arginine residues that is catalyzed by histone methyltransferases.

The first histone demethylase to be discovered was lysine-specific demethylase 1 (LSD1), but further research identified an additional family of histone demethylases; ...