HIV Protease Inhibitors

Human Immunodeficiency Virus (HIV) is an enveloped retrovirus with a positive sense RNA genome. There is high genetic diversity within HIV and these viruses can be split into two families. HIV-1 is more common and is further subdivided into multiple subtypes. HIV-2 is mainly confined with West Africa, although it has been identified globally.

HIV protease is a pepsin-like aspartic protease that is encoded by the viral genome, and is vital for the processing of polyproteins and maturation of ...