HIVEP2 Products

Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular proteinstructure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence.These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancerregions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kband contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).(supplied by OMIM)