HSP70 Inhibitors Small Molecules and Peptides

Hsp70 (70 kDa heat shock protein) is a molecular chaperone that is involved in protein folding and the protection of proteins from damage during stress. The expression of Hsp70 is increased under conditions of thermal stress or in the presence of toxic chemicals such as heavy metals.

Hsp70 binds in an ATP-dependent manner to sequences of hydrophobic residues. These can be on nascent polypeptide chains emerging from the ribosome, or exposed on other proteins by stress conditions. Binding by Hsp70 ...