3 results for "IRAK Inhibitors" in 产品

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IRAK Inhibitors

The IRAK (Interleukin-1 receptor-associated kinases) family of serine-threonine kinases, EC 2.7.11.1, consists of four members, IRAK1, IRAK2, IRAK3 (IRAK-M) and IRAK4. IRAK1/2 have ubiquitous tissue expression, whereas IRAK3 is expressed by monocytes and macrophages, and IRAK4 is predominantly localized to the liver and kidney. Despite being labelled as serine-threonine kinases, IRAK2/3 have inactive kinase domains.

IRAKs are key regulators of interleukin-1 receptor (IL-1R) and Toll-like ...

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IRAK1/4 Inhibitor I

Catalog #: 5665
(1)
Citations (5)
Product Documents

IRAK4 and IRAK1 inhibitor

Chemical Name: N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide
Purity: ≥98%
IRAK4 and IRAK1 inhibitor

AS 2444697

Catalog #: 5430
(3)
Citations (8)
Product Documents

Potent and selective IRAK4 inhibitor

Chemical Name: N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
Purity: ≥98%
Potent and selective IRAK4 inhibitor

C28

Catalog #: 7546
Product Documents

Potent LMTK3 inhibitor

Chemical Name: 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Purity: ≥98%
Potent LMTK3 inhibitor
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