3 results for "IRE1 alpha Small Molecules and Peptides" in 产品
IRE1 alpha Small Molecules and Peptides
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and upregulates ER molecular chaperones in order to cope with ER stress. UPR is initiated by three ER-localized protein sensors: PERK (PKR-like ER kinase), ATF (activating transcription factor 6), and IRE1 alpha (inositol-requiring enz...
Inhibits IRE1α endoribonuclease activity
| Chemical Name: | 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde |
| Purity: | ≥98% |
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Potent and selective IRE1α inhibitor
| Chemical Name: | 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride |
| Purity: | ≥98% |
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Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
| Chemical Name: | N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine |
| Purity: | ≥98% |
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