IRE1 Inhibitors Small Molecules and Peptides

Inositol-requiring enzyme 1 (IRE1), also known as endoplasmic reticulum to nucleus signaling 1 (ERN1), is a resident transmembrane ER protein with both kinase and endonuclease domains. Both yeast (IRE1) and mammalian (IRE1α) homologs are involved in the degradation of misfolded proteins, as part of the unfolded protein response (UPR). IRE1 (yeast) is involved in the endonucleolytic cleavage of HAC1 mRNA, whereas IRE1α (human) catalyzes the splicing of X-box binding protein (XBP) 1 ...