KCC2 Activators Small Molecules and Peptides

K⁺/Cl^- cotransporter 2 (KCC2, SLC12A5) is a neuron specific membrane protein that is responsible for the maintenance of the low intracellular Cl^- concentration in adult neurons. It is one of four members of the solute carrier 12 (SLC12) family of electroneutral cation-chloride cotransporters and is expressed in most mature mammalian central neurons. KCC2 maintains the intracellular Cl^- concentration by using energy from the electrochemical K⁺ gradient across the plasma membrane to drive Cl^- ...