Kilon/NEGR1 Proteins and Enzymes

Kindred of IgLON (Kilon; also neuronal growth regulator 1 (NEGR1) and neurotractin) is a 46 kDa member of the IgLON family of molecules. This cell adhesion family includes the proteins LAMP, OBCAM, neurotrimin, CEPU-1, AvGP50, and GP55. Human Kilon shares 97% aa sequence identity with mouse and rat Kilon.

Expression of Kilon is restricted to the brain, specifically in the cerebrum, brain stem, and hippocampus, with much less expression in the cerebellum. In the rat, it was shown that Kilon ...