Kynurenine 3-monooxygenase Inhibitors

Kynurenine 3-monooxygenase (KMO, EC 1.14.13.9) is a 56 kDa flavoenzyme that catalyzes the hydroxylation of L-kynurenine (L-Kyn) to 3-hydroxykynurenine (3-HK) in the kynurenine pathway, the major route for tryptophan metabolism.

KMO is found in the liver, kidney and some immune cells and is localized to the outer membrane of mitochondria where it is anchored via its hydrophobic C-terminus, which contains a putative targeting sequence for this location. Both the targeting sequence and a ...