Light-up Aptamers Small Molecules and Peptides

RNA Imaging using Light-up RNA Aptamers

An RNA-based fluorogenic complex or module is made up of two parts, a light-up RNA aptamer, and a fluorogenic cognate dye, the "fluorogen", which binds the light-up RNA aptamer with high affinity. Once bound, the complex becomes highly fluorescent. The light-up RNA aptamer and fluorogen do not fluoresce unless bound to each other, making this system highly effective for RNA imaging.

Light-up RNA Aptamer Principles

A light-up RNA aptamer ...