LpxT Proteins and Enzymes

One third of the lipid A pool is lipid A 1-diphosphate formed by a periplasmic domain of LpxT (Touze, 2008). ybjG, pgpB, and lpxT are paralogs. [More information is available at EcoGene: EG14075]. LpxT is responsible for transfer of a phosphate group from undecaprenyl-pyrophosphate to the position 1 phosphate of approximately one-third of lipid A molecules to create lipid A 1-diphosphate.