Mitochondrial Permeability Transition Pore (MPTP) Small Molecules and Peptides

The mitochondrial permeability transition pore (MPTP) is a Ca²⁺-dependent, nonselective pore located on the inner mitochondrial membrane. It opens in response to elevated matrix Ca²⁺ concentrations, increasing the permeability of the mitochondrial membrane to molecules less than 1.5 kDa in weight, and resulting in cell death.

Under normal physiological conditions, MPTP is closed; if matrix [Ca²⁺] increases, the pore opens, causing /a mitochondrial permeability transition (MPT) and resulting in ...