Neuropeptide S Receptor Antagonists

Neuropeptide S receptor 1 (NPSR1/GPR154) is a G-protein coupled receptor for neuropeptide S (NPS). It is coded for by the NPSR1 gene and has three isoforms that contain seven transmembrane domains, as well as non-functional isoforms which do not show membrane expression. NPSR1 is widely expressed throughout the central nervous system, indicating its involvement in multiple neurophysiological functions. In contrast, the NPS gene is only expressed in isolated cells within the amygdala, ...