NFAT Inhibitors Small Molecules and Peptides

The NFAT (Nuclear Factor of Activated T-Cells) family of transcription factors consists of five members; NFATC1 (NFAT2, NFATc), NFATC2 (NFAT1, NFATp), NFATC3 (NFAT4), NFATC4 (NFAT3) and NFAT5. The transcriptional activity of the NFATC1-C4 isoforms is mediated by the calcium/calmodulin-dependent phosphatase calcineurin. In contrast NFAT5 is calcineurin-independent, being activated by osmotic stress. From here on in NFAT will be used to refer to the NFATC1-C4 isoforms.

Under basal conditions, ...