Nicotinic (a7) Receptor Antagonists Small Molecules and Peptides

α7 is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. In avian tissue α7α8 heteromers also occur and an association between α7 and β2 subunits has been suggested in the mammalian brain. The α7 nAChR is particularly prominent in the hippocampus, where it is found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.

Presynaptic α7 nAChRs are present on glutamate terminals and ...