NKCC Cotransporter Inhibitors

Na+/K+/Cl- Symporters (NKCC) are membrane-bound channels that play a prominent role in a variety of epithelial absorptive and secretory processes and a direct role in cell volume regulation and possibly in cell cycle regulation. NKCCs are members of the SLC12 family of cation-coupled chloride transportersand there are two NKCC isoforms, NKCC1 and NKCC2. NKCC1 is found on almost all cells types and, importantly, is located on the basolateral membrane of secretory epithelia. In contrast NKCC2 is ...