NRAMP2/SLC11A2 Proteins and Enzymes

SLC11A2 is a divalent metal transporter (DMT), which carries iron, manganese, cobalt, nickel, cadmium, lead, copper, and zinc. It participates in cellular iron absorption at the luminal surface of the duodenum as well as in other areas of the body. Mutations in SLC11A2 are associated with hypochromic microcytic anemia with iron overload. Multiple transcript variants encoding different isoforms have been identified.