Oligodendrocyte Marker O1 Products

Oligodendrocytes are myelinating cells within the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction. In many CNS disorders, such as stroke, multiple sclerosis, and spinal cord injury, demyelination of axons contributes to functional deficit. The monoclonal antibodies A2B5, O4, and O1 are frequently used to define distinct stages in the maturation of oligodendrocyte progenitors. In general, A2B5+/O4- defines the most immature oligodendrocyte precursors, O4+/O1- defines intermediate precursors, and O1+ defines oligodendrocytes at a more mature stage.