Patched 2/PTCH2 cDNA Clones

Patched 2 (Ptch2) is a 180 - 200 kDa 12 transmembrane member of the Patched family. Human PTCH2 is 1203 amino acids (aa) in length. It has two terminal cytoplasmic domains, one between aa 1 - 57, and a second between aa 1115 - 1203. Together with Smoothened (SMO), Ptch2 forms a membrane complex that serves as a receptor for Sonic Hedgehog (SHH).