PEDFR/PNPLA2 Proteins and Enzymes

PEDFR (Pigment epithelium derived factor receptor; also ATGL, PNPLA2 and desnutrin) is a 55 kDa member of the PNPLA family of proteins. It is expressed in adipocytes, hepatocytes, skeletal muscle and pigment epithelium. PEDFR specifically hydrolyses triglycerides, releasing long-chain fatty acids.

Mouse PEDFR is described as being a 486 amino acid (aa) type II transmembrane (TM) protein. Its TM segment is stated to span aa 9 - 29. Alternatively, it may have a hydrophobic lipid-association ...