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Prion Protein Compounds Small Molecules and Peptides

Cellular prion protein (PrPC) is a cell surface glycoprotein encoded by the PRNP gene in humans. It is highly expressed in the CNS and PNS, where it is found on neurons, astrocytes, oligodendrocytes and microglia; it is also found in multiple peripheral organs and on immune cells. PrPC is an evolutionarily conserved protein indicating a critical physiological function, however it is also a cause of pathogenesis in neurodegenerative prion diseases.

The physiological roles of PrPC are poorly ...

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Filipin III

Catalog #: 6250
(1)
Citations (4)
Product Documents

Fluorescent cholesterol stain, also polyene antibiotic. Used for: Fluorescent cholesterol stain. Binds sterol in fungal membranes. Application: confocal microscopy

Chemical Name: (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Purity: ≥90%
Fluorescent cholesterol stain; also polyene antibiotic

Anle138b

Catalog #: 6861
Product Documents

Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation

Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
Purity: ≥98%
Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation
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