8 results for "Protein Kinase A Inhibitors" in 产品
Protein Kinase A Inhibitors
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the regulatory subunit (RIα- and RIβ-, RIIα- and RIIβ-).
Binding of cAMP to the regulatory subunit releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).
Protein kinase A inhibitor
| Chemical Name: | N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride |
| Purity: | ≥98% |
Selective protein kinase A inhibitor
| Chemical Name: | (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester |
| Purity: | ≥97% |
Cell-permeable protein kinase A inhibitor
| Alternate Names: | Protein kinase inhibitor-(14-22)-amide,myristoylated |
| Purity: | ≥95% |
cAMP antagonist
| Chemical Name: | (R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium |
| Purity: | ≥98% |
Inhibitor of cyclic nucleotide dependent- and Rho-kinases
| Alternate Names: | HA 1077 |
| Purity: | ≥98% |
High affinity PKA inhibitor
| Purity: | ≥95% |
Potent pan-Akt and PKA inhibitor
| Chemical Name: | 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride |
| Purity: | ≥98% |
Staurosporine synthesized to Ancillary Material Grade
| Chemical Name: | [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one |
| Purity: | ≥98% |
