PTH2R Small Molecules and Peptides

PTHR2, a Parathyroid Hormone Receptor, binds parathyroid hormone (PTH), parathyroid hormone-related peptide, and tuberoinfundibular peptide 39 (TIP39). However, parathyroid hormone-related peptide does not activate the receptor. The physiologic role of PTHR2 and its possible role in disease remained to be determined. PTHR2 has been reported in brain. ESTs have been isolated from normal testis libraries as well as cancer libraries from bone marrow, brain, germ cell, head/neck, and skin.