RAGE Antagonists Small Molecules and Peptides

The receptor for advanced glycation end-products (RAGE; AGER) is a multiligand cell surface protein belonging to the immunoglobulin (Ig) superfamily. RAGE acts as a pattern recognition receptor (PRR) and is involved in inflammation and the immune response.

RAGE is composed of an extracellular V domain, which binds multiple ligands, 2 C-type immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail, which is required for RAGE-mediated signaling. Interestingly unlike many ...