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1 result for "Ras GTPase Degraders Small Molecules and Peptides" in 产品
Ras GTPase Degraders Small Molecules and Peptides
RAS Structure and Function
There are three human RAS genes; HRAS, KRAS and NRAS, which encode four highly related 188-189 amino acid proteins, HRAS, KRAS4A, KRAS4B and NRAS. KRAS encodes two spice variants, with 4B being widely expressed and 4A more tissue restricted. The C-terminal 24/25 amino acid sequence exhibits the greatest divergence between the different isoforms and contain sequences that facilitate membrane interactions.
Ras proteins function as GDP-GTP regulated binary on-off ...
Selective KRAS Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥95% |
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