RCBTB1 Proteins and Enzymes

Residing in the cytoplasm and nucleus, RCBTB1 is involved in cell cycle regulation by chromatin remodeling. More specifically, RCBTB1 encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB domain. This gene interacts with MAP1LC3B, ATG16L1, CLN3, FYCO1 and GABARAP. Mapping to chromosome 13q in humans, this gene is commonly deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. Common diseases associated with RCBTB1 include alcoholism, asthma, hypertrophy and chronic lymphocytic leukemia.