Rev-Erb Receptor Antagonists Small Molecules and Peptides

Rev-Erb receptors are orphan nuclear receptors belonging to the NR1D receptor family. There are two family members, Rev-Erbα (NR1D1) and Rev-Erbβ (NR1D2). Rev-Erb receptors are thought to share many target genes with retinoic acid receptor-related orphan receptors (RORs), and both groups recognize a number of the same DNA response elements. Furthermore, Rev-Erbs and RORs are coexpressed in adipose tissue, liver, skeletal muscle and brain, and play a central role in circadian rhythm ...