RGR Proteins and Enzymes

Retinal G protein-coupled receptor RPE, a member of the Opsin subfamily of GPCRs has been shown to be involved in retinitis pigmentosa. It preferentially binds all-trans retinal rather than 11-cis retinal, which is normally found in rhodopsin. RPE has two isoforms produced by alternative splicing. Retinal G protein-coupled receptor RPE has been reported to be expressed in the eye. ESTs have been isolated from normal human brain and eye libraries and from human brain and colon cancer libraries.