TMPRSS2 Inhibitors

Transmembrane protease, serine 2 (TMPRSS2) is a serine protease with a type II transmembrane domain and an extracellular serine protease domain, which preferentially cleaves substrates at basic residues. TMPRSS2 is expressed in human bronchial epithelial cells, nasal goblet cells, small intestine epithelia, the prostate, gastrointestinal tract, kidneys and pancreas, with highest expression levels found in the prostate.The normal physiological role of TMPRSS2 is unknown, however its expression ...