TOB1 Proteins and Enzymes

Transducer of ERBB2, 1 (TOB1), also known as TOB, is a 345 amino acid (aa) member of the BTG/TOB family of proteins with a predicted molecular weight of 38 kDa. The members of this protein family are characterized by a B Cell Translocation Gene (BTG) homology domain. Human TOB1 shares 96% aa sequence identity with the mouse and rat orthologs. TOB1 has antiproliferative activity that is at least partially mediated by its ability to promote mRNA deadenylation and negatively regulate Cyclin D1 ...