Trace Amine 1 (TA1) Receptor Antagonists

The trace amine 1 (TA₁) receptor (also known as the trace amine-associated receptor 1, TAAR1) is a class A GPCR that is activated by endogenous trace amines such as β-phenylethylamine, tyramine and octopamine. Trace amines differ from classic biogenic amines, such as serotonin and histamine, in that they are present only at trace levels due to rapid hydrolysis by monoamine oxidase. The role of trace amines in vertebrates is not yet fully understood, but neuromodulatory functions have been ...