Two-P Potassium Channel Inhibitors

Two-P potassium channels (K_2P) are a family of proteins responsible for background potassium currents, which are important in stabilizing membrane potential. K_2Ps are so called because each subunit contains four transmembrane and two pore domains (P loops), although they do not form two pores; it is this 4TM/2P formation that characterizes the members of the K_2P channel family. They are thought to form functional dimers within the membrane. Fifteen K_2P channels have been identified to date, ...