WDR51A Proteins and Enzymes

POC1 centriolar protein homolog A (POC1A), also known as Pix2 and WD repeat-containing protein 51A (WDR51A), is a member of the WD repeat POC1 family. WDR51A functions to control centriole length and duplication. Additionally, WDR51A is required for ciliogenesis and basal body formation. Mutations to the WDR51A gene result in short stature, onychodysplasia, facial dysmorphism, hypotrichosis (SOFT) syndrome, abnormal cellular mitotic mechanisms and impaired ciliogenesis.