Wnt-10a Proteins and Enzymes

Wnt-10a is a presumably secreted, glycosylated member of the Wnt family of developmental proteins. Mouse Wnt-10a is synthesized as a 417 amino acid (aa) precursor that contains a 382 aa mature region. The mature region contains 24 cysteines and two potential N-linked glycosylation sites. Mature mouse Wnt-10a is 96% and 99% aa identical to mature human and rat Wnt-10a, respectively. Wnt-10a is 64% aa identical to Wnt-10b/12. Wnt-10a is produced by tumors and thymic epithelium.

The Wnts make ...