Single Cell Dispensing Applications
Supported by Your Peers and Peer-reviewed Research
The Pala Single Cell Sorter and Dispenser is trusted by professionals from both industry and academia and backed by publications in top tier journals. Learn more about how Pala can scale your single cell applications below.
“The introduction of the Pala Single Cell Dispenser has brought significant reduction in sorting time and cost of goods. The device is small, quick to set up and easy-to-use with high probability of monoclonality and clonal outgrowth.”
– Lina Chakrabarti, PhD
Principal Scientist/Director of R&D, AstraZeneca
Biologics Cell Line Development
Biologics manufacturing demands productive, stable, and well characterized cell lines derived from single cell clones. Isolating clones with the highest yields and optimal growth rates can demand high-throughput single cell cloning capabilities. Pala offers an efficient alternative to manual pipetting and labor-intensive FACS sorting, enabling faster and more scalable CHO cell line development.
Gene Editing
CRISPR editing is driving growing demand for development of disease model cell lines and novel therapies. iPSCs and stem cells paired with CRISPR offer tremendous potential for advancing research and medicine. However, iPSC cell line development remains technically challenging and labor-intensive. Pala’s gentle sorting combined with 2-laser fluorescence enables higher rates of single cell cloning success with these sensitive cell types.
Single Cell Multiomics
Technologies for studying genomics, transcriptomics, and proteomics in single cells have exploded in the last decade. Isolation of single cells for plate-based -omics approaches require high single cell dispensing accuracy, controlled dispense volumes, gentle cell handling, and fluorescence sorting. Learn how Pala’s unique combination of features excels above other single cell dispensing technologies to support -omics applications.
Cell & Gene Therapy Development
Development of precision gene editing tools have enabled the invention of novel cell and gene therapies for patients with debilitating diseases such as cancer, rare genetic diseases, and autoimmune disorders. These novel therapies require intensive cell line development activities for both production and testing purposes. Pala’s closed cartridge design, combined with gentle and fast single cell isolation, is ideal for incorporation into cell and gene therapy workflows.
