Chemical Name: 3-[2-(Dimethylamino)ethyl]-1-methylindol-4-ol
Biological ActivityPotent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively). Displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Active in vivo; inhibits scratching in a mouse model of OCD.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
SAR of psilocybin analogs: discovery of a selective 5-HT2C agonist.
Sard et al.
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