Catalog Number: 0558
Biological Activity
5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM).
Technical Data
  • M.Wt:
    226.71
  • Formula:
    C11H14N2O.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    845861-49-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors.
    Glennon et al.
    J.Med.Chem., 2000;43:1011
  2. 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin.
    Ismaiel et al.
    J.Med.Chem., 1990;33:755
  3. 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.
    Craig et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1990;342:9
  4. 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs.
    Wilson et al.
    J.Pharmacol.Exp.Ther., 1990;252:683

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