4-HQN

Key Product Details

Product Description

Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC₅₀ = 9.5 μM); displays mixed inhibition with respect to NAD⁺. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.

Product Specifications for 4-HQN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 4-HQN

The following data is based on the product molecular weight 146.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.84 mL	34.21 mL	68.42 mL
5 mM	1.37 mL	6.84 mL	13.68 mL
10 mM	0.68 mL	3.42 mL	6.84 mL
50 mM	0.14 mL	0.68 mL	1.37 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Halmosi Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol.Pharmacol. 2001 PMID: 11353811
• Veres Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J.Pharmacol.Exp.Ther. 2004 PMID: 14999056
• Banasik Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J.Biol.Chem. 1992 PMID: 1530940

Product Documents for 4-HQN