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4-HQN

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4-HQN | CAS No. 491-36-1 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: PARP inhibitor

Chemical Name: 4-(1H)-Quinazolinone

Purity: ≥99%

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Biological Activity

Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.

Technical Data

M.Wt:
146.15
Formula:
C8H6N2O
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
491-36-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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