Potent competitive vanilloid TRPV1 (VR1) receptor antagonist (IC50
= 10 nM). Inhibits capsaicin-induced [Ca2+
increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.
Appendino et al.