Biological ActivityPotent competitive vanilloid TRPV1 (VR1) receptor antagonist (IC50 = 10 nM). Inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro.
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Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.
Appendino et al.
Citation for 6-Iodonordihydrocapsaicin
The citations listed below are publications that use Tocris products. Selected citations for 6-Iodonordihydrocapsaicin include:
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Effects of luminal thymol on epithelial transport in human and rat colon.
Authors: Kaji Et al.
Am J Physiol Gastrointest Liver Physiol 2011;300:G1132
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