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6-Iodonordihydrocapsaicin

1975 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1975/5
1975/25
6-Iodonordihydrocapsaicin | CAS No. 859171-97-4 | TRPV Antagonists
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Description: Potent, competitive vanilloid receptor antagonist

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Potent competitive vanilloid TRPV1 (VR1) receptor antagonist (IC50 = 10 nM). Inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro.

Technical Data

M.Wt:
419.3
Formula:
C17H26INO3
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
859171-97-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.
    Appendino et al.
    Br.J.Pharmacol., 2003;139:1417

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Citation for 6-Iodonordihydrocapsaicin

The citations listed below are publications that use Tocris products. Selected citations for 6-Iodonordihydrocapsaicin include:

1 Citation: Showing 1 - 1

  1. Effects of luminal thymol on epithelial transport in human and rat colon.
    Authors: Kaji Et al.
    Am J Physiol Gastrointest Liver Physiol  2011;300:G1132

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VersaClone cDNA Plasmids

Rat Vanilloid R1/TRPV1 (NP_114188) VersaClone cDNA

RDC1967

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