Catalog Number: 4061
Alternate Names: 6-TG
Chemical Name: 2-Amino-6-mercaptopurine
Biological Activity
Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 6-Thioguanine perturbs cytosine methylation at CgP dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.
    Wang and Wang
    Biochemistry, 2009;48:2290
  2. 6-Thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.
    Issaeva et al.
    Cancer Res., 2010;70:6268
  3. 6-thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1.
    Yuan et al.
    Cancer Res., 2011;71:1904
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