6,8-Bis(benzylthio)octanoic acid

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6,8-Bis(benzylthio)octanoic acid | CAS No. 95809-78-2 | Dehydrogenase Inhibitors
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Description: PDH and KGDH inhibitor

Chemical Name: 6,8-Bis[(phenylmethyl)thio]octanoic acid

Purity: ≥99%

Product Details
Citations (1)

Biological Activity

6,8-Bis(benzylthio)octanoic acid is a pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro. Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for 6,8-Bis(benzylthio)octanoic acid

The citations listed below are publications that use Tocris products. Selected citations for 6,8-Bis(benzylthio)octanoic acid include:

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