A 350619 hydrochloride

Key Product Details

Product Description

A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo.

Product Specifications for A 350619 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 350619 hydrochloride

The following data is based on the product molecular weight 425.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.75 mL	23.51 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.24 mL	1.18 mL	2.35 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Evgenov NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 2006 PMID: 16955067
• Kotzki Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J.Pharmacol.Exp.Ther. 2013 PMID: 23838678
• Miller A-350619: a novel activator of soluble guanylyl cyclase. Life Sci. 2003 PMID: 12495780

Product Documents for A 350619 hydrochloride