Activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro
and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo
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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential.
Evgenov et al.
Nat.Rev.Drug Discov., 2006;5:755
A-350619: a novel activator of soluble guanylyl cyclase.
Miller et al.
Life Sci., 2003;72:1015
Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats.
Kotzki et al.