A 350619 hydrochloride
Chemical Name: 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride
Purity: ≥99%
Biological Activity
A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential.
Evgenov et al.
Nat.Rev.Drug Discov., 2006;5:755 -
A-350619: a novel activator of soluble guanylyl cyclase.
Miller et al.
Life Sci., 2003;72:1015 -
Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats.
Kotzki et al.
J.Pharmacol.Exp.Ther., 2013;346:424
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