A 943931 dihydrochloride

Key Product Details

Product Description

A 943931 dihydrochloride is a potent and selective histamine H₄ receptor antagonist (pK_i values are 7.15 and 8.12 at human and rat receptors respectively). Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models.

Product Specifications for A 943931 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 943931 dihydrochloride

The following data is based on the product molecular weight 368.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.58 mL	27.15 mL
5 mM	0.54 mL	2.72 mL	5.43 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Leurs Molecular and biochemical pharmacology of the histamine H₄ receptor. Br.J.Pharmacol. 2009 PMID: 19413568
• Aldi Histamine H4-Receptors Inhibit Mast Cell Renin Release in Ischemia/Reperfusion via PKC{epsilon}-Dependent Aldehyde Dehydrogenase Type-2 Activation. J.Pharmacol.Exp.Ther. 2014 PMID: 24696042
• Cowart Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H₄ receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 2008 PMID: 18817367

Product Documents for A 943931 dihydrochloride