A2B5 Alexa Fluor® 350-conjugated Antibody

FAB1416U 1 Citation Datasheet / COA / SDS

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FAB1416U-100UG

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A2B5 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat, Chicken

Specificity

Recognizes the A2B5 cell surface ganglioside epitope found on type II astrocytes, cells involved in gliogenesis, and cells committed to the oligodendrocyte lineage (1‑4).

Source

Monoclonal Mouse IgM Clone # 105

Immunogen

Embryonic chicken retinal cells

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25-1 µg/10⁶ cells

NTera‑2 human testicular embryonic carcinoma cell line treated with retinoic acid

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: A2B5

A2B5 is a cell surface ganglioside epitope expressed in developing thymic epithelial cells, oligodendrocyte progenitors, and neuroendocrine cells (1).

References

Eisenbarth, G.S. et al. (1979) Proc. Natl. Acad. Sci. USA 76:4913.
Bottenstein, J.E. et al. (1988) J. Neurosci. Res. 20:291.
Suzumura, A. and D.H. Silberberg (1989) Brain Res. 480:51.
Dubois-Dalcq, M. et al. (1990) Cellular and Molecular Biology of Myelination, Springer-Verlag, pp. 3.

Alternate Names

A2B5 marker; A2B5

Product Datasheets

Product Datasheet

COA

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Related Research Areas

Citation for A2B5 Alexa Fluor® 350-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

The interleukin-4/PPARÎ³ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury
Authors: Q Zhang, W Zhu, F Xu, X Dai, L Shi, W Cai, H Mu, TK Hitchens, LM Foley, X Liu, F Yu, J Chen, Y Shi, RK Leak, Y Gao, J Chen, X Hu
PLoS Biol., 2019;17(6):e3000330.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry