Chemical Name: 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
Biological Activity High affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.
Soluble to 100 mM in water and to 20 mM in DMSO
Desiccate at RT
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