High affinity and selective α
2 partial agonist (Ki
= 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α
2 over α
1 and α
7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro
. Enhances cognitive performance in vivo
. Orally bioavailable and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.
Rueter et al.
CNS Drug Rev., 2004;10:167
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties.
Sullivan et al.
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys.
Decker et al.