Human nAChR alpha 4/CHRNA4 (NP_000735) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Human nAChR alpha 4/CHRNA4 (NP_000735) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: Nicotinic Acetylcholine R alpha 4/CHRNA4

CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. CHRNA4 is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in CHRNA4 cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in CHRNA4 that provide protection against nicotine addiction have been described.

Long Name
Nicotinic Acetylcholine Receptor alpha 4
Entrez Gene IDs
1137 (Human); 11438 (Mouse); 25590 (Rat)
Alternate Names
nAchRa4; BFNC; cholinergic receptor, nicotinic, alpha 4; cholinergic receptor, nicotinic, alpha polypeptide 4; CHRNA4; EBN; EBN1; ENFL1; FLJ95812; nAChR alpha 4; NACHR; NACHRA4; NACRA4; neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha-4 subunit; Nicotinic Acetylcholine R alpha 4; Nicotinic Acetylcholine Ra4


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