AC 55541

Catalog # Availability Size / Price Qty
3369/10
3369/50
AC 55541 | CAS No. 916170-19-9 | Protease-Activated Receptor Agonists
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Description: Potent and selective PAR2 agonist

Chemical Name: (2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide

Purity: ≥97%

Product Details
Citations (6)
Supplemental Products
Reviews

Biological Activity

Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

Technical Data

M.Wt:
518.36
Formula:
C25H20BrN5O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
916170-19-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of potent and selective small-molecule PAR-2 agonists.
    Seitzberg et al.
    J.Med.Chem., 2008;51:5490
  2. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists.
    Gardell et al.
    J.Pharmacol.Exp.Ther., 2008;327:799

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