AC 55541

Key Product Details

Product Description

AC 55541 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca²⁺ mobilization in vitro (pEC₅₀ values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

Product Specifications for AC 55541

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AC 55541

The following data is based on the product molecular weight 518.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.86 mL	19.29 mL	38.58 mL
2.5 mM	0.77 mL	3.86 mL	7.72 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
25 mM	0.08 mL	0.39 mL	0.77 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Gardell Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 2008 PMID: 18768780
• Seitzberg Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 2008 PMID: 18720984

Product Documents for AC 55541