Chemical Name: (2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide
Biological ActivityAC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of potent and selective small-molecule PAR-2 agonists.
Seitzberg et al.
Identification and characterization of novel small-molecule protease-activated receptor 2 agonists.
Gardell et al.
Citations for AC 55541
The citations listed below are publications that use Tocris products. Selected citations for AC 55541 include:
6 Citations: Showing 1 - 6
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
Authors: Shi Et al.
JCI Insight 2019;5
Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression.
Authors: Melo Et al.
Cell Death Dis 2019;10:659
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
J Immunol 2015;21:4852
A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
Authors: White Et al.
Mol Pain 2015;194:142
Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
Authors: Tripathi Et al.
Invest Ophthalmol Vis Sci 2014;55:3912
Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.
Authors: Alkhani Et al.
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