Catalog Number: 3369
Chemical Name: (2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide
Biological Activity
Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.
Technical Data
  • M.Wt:
    518.36
  • Formula:
    C25H20BrN5O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    916170-19-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of potent and selective small-molecule PAR-2 agonists.
    Seitzberg et al.
    J.Med.Chem., 2008;51:5490
  2. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists.
    Gardell et al.
    J.Pharmacol.Exp.Ther., 2008;327:799

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