Home / Calpain Inhibitors / Acetyl-Calpastatin (184-210) (human)

Acetyl-Calpastatin (184-210) (human)

2950 3 Citations Datasheet / COA / SDS
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2950/1
Acetyl-Calpastatin (184-210) (human)
1 Image
Description: Selective calpain inhibitor
Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Acetyl-Calpastatin (184-210) (human) is a selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data

M.Wt:
3177.65
Formula:
C142H230N36O44S
Sequence:
DPMSSTYIEELGKREVTIPPKYRELLA

(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
123714-50-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene.
    Maki et al.
    J.Biol.Chem., 1989;264:18866
  2. Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition.
    Yamazaki et al.
    Biochem., 1997;36:8377
  3. A new cell-permeable calpain inhibitor.
    Fiorino et al.
    J.Peptide Sci., 2007;13:70

Product Datasheets

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Citations for Acetyl-Calpastatin (184-210) (human)

The citations listed below are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:

3 Citations: Showing 1 - 3

  1. Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons.
    Authors: Gerónimo-Olvera Et al.
    Cell Death Dis  2017;8:e2911
  2. Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
    Authors: Alvarez-Arce
    Int J Cell Biol  2017;2017:1908310
  3. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment.
    Authors: Davis Et al.
    Hypertension  2016;1:e86355

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