Acetyl-Calpastatin (184-210) (human)

  ( 3 citations )    
Product Datasheet
Catalog Number:2950
Chemical Name:
Product Details
Citations (3)
Reviews
Biological Activity
Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
Technical Data
  • M.Wt:
    3177.65
  • Formula:
    C142H230N36O44S
  • Sequence:
    DPMSSTYIEELGKREVTIPPKYRELLA

    (Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

  • Solubility:
    Soluble to 5 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    123714-50-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:

3 Citations: Showing 1 - 3
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  1. Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons.
    Authors: Gerónimo-Olvera Et al.
    Cell Death Dis  2017;8:e2911
  2. Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
    Authors: Alvarez-Arce
    Int J Cell Biol  2017;2017:1908310
  3. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment.
    Authors: Davis Et al.
    Hypertension  2016;1:e86355

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