Acetyl-Calpastatin (184-210) (human)

Catalog # Availability Size / Price Qty
2950/1
Acetyl-Calpastatin (184-210) (human)
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Description: Selective calpain inhibitor
Product Details
Citations (3)
Reviews

Biological Activity

Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data

M.Wt:
3177.65
Formula:
C142H230N36O44S
Sequence:
DPMSSTYIEELGKREVTIPPKYRELLA

(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
123714-50-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene.
    Maki et al.
    J.Biol.Chem., 1989;264:18866
  2. Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition.
    Yamazaki et al.
    Biochem., 1997;36:8377
  3. A new cell-permeable calpain inhibitor.
    Fiorino et al.
    J.Peptide Sci., 2007;13:70

Product Datasheets

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Citations for Acetyl-Calpastatin (184-210) (human)

The citations listed below are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:

3 Citations: Showing 1 - 3

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