Acetyl-Calpastatin (184-210) (human)

Name: Acetyl-Calpastatin (184-210) (human)
Brand: Tocris Bioscience
SKU: 2950

Tocris Bioscience | Catalog # 2950

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Citations (12)

Product Documents

Selective calpain inhibitor

Discontinued Product

2950 has been discontinued. View all Calpain Inhibitors products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Selective calpain inhibitor

View all Calpain Inhibitors »

Product Description

Acetyl-Calpastatin (184-210) (human) is a selective calpain inhibitor. Strongly inhibits calpain I (K_i = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (K_i = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Product Specifications for Acetyl-Calpastatin (184-210) (human)

Molecular Weight

3177.65

Formula

C₁₄₂H₂₃₀N₃₆O₄₄S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

123714-50-1

PubChem ID

90488788

InChI Key

ZXJCOYBPXOBJMU-HSQGJUDPSA-N

SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 5mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Yamazaki Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem.
Fiorino A new cell-permeable calpain inhibitor. J.Peptide Sci.
Maki Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 1989 PMID: 2553724

Product Documents for Acetyl-Calpastatin (184-210) (human)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Acetyl-Calpastatin (184-210) (human)

For research use only

Related Research Areas

Cysteine Proteases and Regulators

Citations for Acetyl-Calpastatin (184-210) (human)

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