Catalog Number: 2950
Biological Activity
Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

  • Solubility:
    Soluble to 5 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene.
    Maki et al.
    J.Biol.Chem., 1989;264:18866
  2. Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition.
    Yamazaki et al.
    Biochem., 1997;36:8377

The citations listed below are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:

Showing Results 1 - 1 of 1

  1. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment.
    Authors: Davis Et al.
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