Selective calpain inhibitor. Strongly inhibits calpain I (Ki
= 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki
= 6 μ
M). Increases secretion of amyoid β
) 42, Aβ
40 and Aβ
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All Tocris products are intended for laboratory research use only.
Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene.
Maki et al.
Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition.
Yamazaki et al.
The citations listed below are publications that use Tocris products. Selected citations for Acetyl-Calpastatin (184-210) (human) include:
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