Catalog Number: 1112
Chemical Name: (1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Biological Activity
Competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).
Technical Data
  • M.Wt:
    217.18
  • Formula:
    C8H11NO6
  • Solubility:
    Soluble to 5 mM in DMSO and to 100 mM in 1.4 eq. NaOH
  • Storage:
    Desiccate at -20°C
  • CAS No:
    195209-04-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the CNRS
Background References
  1. Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.
    Bessis et al.
    Proc.Natl.Acad.Sci.U.S.A., 2002;99:11097
  2. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.
    Acher et al.
    J.Med.Chem., 1997;40:3119
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ACPT-II include:

2 Citations: Showing 1 - 2
Filter your results:

  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Int J Mol Sci 2000;97:11593

Have you used ACPT-II?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information